Adult Protocols
Adult Protocols

Nevada Cancer Research Center
Type Group/Study Description
AML
ECOG E2906
Phase III Randomized Trial Of Clofarabine As Induction And Post-Remission Therapy Versus Standard Daunorubicin & Cytarabine Induction And Intermediate Dose Cytarabine Post-Remission Therapy, Followed By Decitabine Maintenance Versus Observation In Newly-Diagnosed Acute Myeloid Leukemia In Older Adults 
AML
ECOG E3903
Comparing Three Different Combination Chemotherapy Regimens In Treating Patients With Relapsed Or Refractory Acute Myeloid Leukemia
Bladder
CALGB 90601
A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, And Bevacizumab To Gemcitabine, Cisplatin, And Placebo In Patients With Advanced Transitional Cell Carcinoma
Brain
NCCTG N0872
Phase I/Randomized Phase II Double Blind Study of Either Dasatinib or Placebo Combined with Bevacizumab in Recurrent Glioblastoma (Study 2 Phase II)
Breast Adjuvant
NSABP B-47
A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer
Breast Adjuvant
NSABP B-49
A Phase III Clinical Trial Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women with Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer.
Breast Adjuvant
RTOG 1005
A Phase III Trial Of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost For Early-Stage Breast Cancer
Breast Adjuvant
SWOG S1007

A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and Her2-Negative Breast Cancer with Recurrence Score (RS) of 25 or less.

Breast Local Metastatic
ECOG E3108
This study was suspended on 6/21/13

A Phase II Prospective Trial Correlating Progression Free Survival with CYP2D6 Activity in Patients with Metastatic Breast Cancer Treated with Single Agent Tamoxifen

Breast Surgery
ACOSOG Z11102

Impact of Breast Conservation Surgery on Surgical Outcomes and Cosmesis in Patients with Multiple Ipsilateral Breast Cancers (MIBC)

Carcinoid / Neuroendocrine
Alliance A021202
Prospective Randomized Phase II Trial of Pazopanib
(NSC #737754) versus Placebo in Patients with Progressive Carcinoid Tumors
Cancer Control
Alliance A221101
A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (NuvigilĀ®) To Reduce Cancer-Related Fatigue in Patients with Glioblastoma Multiform.
Cancer Control
CALGB 70807
The Men's Eating and Living (MEAL) Study: A Randomized Trial of Diet to Alter Disease Progression in Prostate Cancer Patients on Active Surveillance.
Cancer Control
ECOG E1Z11
A Cohort Study to Evaluate Genetic Predictors for Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS)
Cancer Control
NSABP B-43

A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with Her2-Positive Ductal Carcinoma in Situ Resected by Lumpectomy

Cancer Control
SWOG S0702
A Prospective Observational Multicenter Cohort Study to Assess The Incidence of Osteonecrosis of the Jaw (ONJ) in Cancer Patients with Bone Metastases Starting Zoledronic Acid Treatment.
Cancer Control
SWOG S0820
A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients with Stage 0-III Colon Cancer, Phase III - Preventing Adenomas of the Colon with Eflornithine and Sulindac (PACES)
Cancer Control
URCC UCCO08106
A Study of the Effects of Exercise on Cancer-Related Fatigue
Cancer Control
URCC 10055
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy at Pre-treatment, Post-treatment, and at Six Month Follow-up.
CLL
ECOG E1908
A Phase II Randomized Trial Comparing Standard And Low Dose Rituximab: Initial Treatment Of Progressive Chronic Lymphocytic Leukemia In Elderly Patients Using Alemtuzumab And Rituximab
Colon
CALGB 80702
A Phase III Trial of 6 Versus 12 Treatments of Adjuvant FOLFOX Plus Celecoxib or Placebo for Patients with Resected Stage III Colon Cancer..
Endometrial
GOG 0258
A Randomized Phase III Trial Of Cisplatin And Tumor Volume Directed Irradiation Followed By Carboplatin And Paclitaxel Vs. Carboplatin And Paclitaxel For Optimally Debulked, Advanced Endometrial Carcinoma"
Esophagus
RTOG 1010
Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of Her2-Overexpressing Esophageal Adenocarcinama
Head & Neck
ECOG E1305
A Phase III Randomized Trial Of Chemotherapy With Or Without Bevacizumab In Patients With Recurrent Or Metastatic Head And Neck Cancer
Head & Neck
RTOG 0920
A Phase III Study Of Postoperative Radiation Therapy (Imrt) +/- Cetuximab For Locally-Advanced Resected Head And Neck Cancer
Head & Neck
Salivary
RTOG 1008
A Randomized Phase II Study Of Adjuvant Concurrent Radiation And Chemotherapy Versus Radiation Alone In Resected High-Risk Malignant Salivary Gland Tumors
Liver
CALGB 80802
Phase III randomized study of sorafenib (IND 69896, NSC 724772) plus doxorubicin versus sorafenib in patients with advanced hepatocellular carcinoma (HCC)s
Liver/Biliary
SWOG S1310
Randomized Phase II Trial of Single Agent MEK Inhibitor Trametinib (GSK1120212) Vs 5-Fluorouracil or Capecitabine in Refractory Advanced Biliary Cancer
Lung Cancer
Non-Small Cell
CALGB 30607

 

Randomized, Phase III, Double-Blind Placebo-Controlled Trial Of Sunitinib As Maintenance Therapy In Non-Progressing Patients Following An Initial Four Cycles Of Platinum-Based Combination Chemotherapy In Advanced, Stage IIIB/IV Non-Small Cell Lung Cancer
Lung Cancer
Non-Small Cell
RTOG 0813

 

Seamless Phase I/II Study Of Stereotactic Lung Radiotherapy (SBRT) For Early Stage, Centrally Located, Non-Small Cell Lung Cancer (NSCLC) In Medically Inoperable Patients 
Lung Cancer
Non-Small Cell
SWOG S0819

 

A Randomized, Phase III Study Comparing Carboplatin/Paclitaxel Or Carboplatin/Paclitaxel/Bevacizumab With Or Without Concurrent Cetuximab In Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Lung Cancer
Non-Small Cell
ECOG E1512
A Randomized Phase II Trial Of Erlotinib, Cabozantinib, Or Erlotinib Plus Cabozantinib As 2nd Or 3rd Line Therapy In Patients With EGFR Wild-Type NSCLC
Lung Cancer
Small Cell
CALGB 30610
Phase III Comparison Of Thoracic Radiotherapy Regimens In Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin And Etoposide
Lung Cancer
Small Cell
RTOG 0937
Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone To Prophylactic Cranial Irradiation And Consolidative Extra-Cranial Irradiation For Extensive Disease Small Cell Lung Cancer
Lymphoma Central Nervous System
RTOG 1114
Phase II Randomized Study Of Rituximab, Methotrexate, Procarbazine, Vincristine, And Cytarabine With And Without Low-Dose Whole-Brain Radiotherapy For Primary Central Nervous System Lymphoma
Lymphoma Large B-Cell
CALGB 50303
Phase III Randomized Study of R-CHOP V. Dose-Adjusted EPOCH-R with Molecular Profiling in Untreated De Novo Diffuse Large B-Cell Lymphomas
Lymphoma Non-Hodgkins
CALGB 50904
A Randomized Phase II Trial of Ofatumumab and Bendamustine vs. Ofatumumab, Bortezomib (NSC #681239, IND #58443) and Bendamustine in Patients with Untreated Follicular Lymphoma
Lymphoma Large B-Cell
ECOG 1412
E1412, Randomized Phase II Open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma
MDS / Anemia
ECOG E2905
Randomized Phase III Trial Comparing The Frequency Of Major Erythroid Response (MER) To Treatment With Lenalidomide (Revlimid(R)) Alone And In Combination With Epoeitn Alfa (Procrit(R)) In Subjects With Low- Or Intermediate-1 Risk MDS And Symptomatic Anemia.
Melanoma
ECOG E1609
A Phase III Randomized Study Of Adjuvant Ipilimumab Anti-Ctla4 Therapy Versus High-Dose Interferon Alfa-2b For Resected High-Risk Melanoma
Melanoma
NCCTG N0879
A Randomized Phase II Trial Of Carboplatin, Paclitaxel, Bevacizumab With Or Without Everolimus For Therapy For Metastatic Malignant Melanoma
Mesothelioma
CALGB 30901
Randomized Phase II Study Of Maintenance Pemetrexed Versus Observation For Patients With Malignant Pleural Mesothelioma Without Progression After First-Line Chemotherapy
Metastatic
RTOG 0631
A Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis
Multiple Myeloma
CONNECT MM
Registry Is To Explore The Natural History And Real World Management Of Patients With Newly Diagnosed Symptomatic Multiple Myeloma (MM) And Provide Unique Insights Into The Management Of Mm And The Impact Of This Hematologic Disorder On Patients.
Multiple Myeloma
ECOG E3A06
Randomized Phase III Trial Of Lenalidomide Versus Observation Alone In Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma 
Pancreas
E2211
A Randomized Phase II Study of Temozolomide or Temozolomide and Capecitabine in Patients with Advanced Pancreatic Neuroendocrine Tumors
Pancreas
SWOG 1115
Randomized Phase II Clinical Trial of AZD6244 Hydrogen Sulfate (NSC-748727) and MK-2206 (NSC-749607) VS mFOLFOX in Patients with Metastatic Pancreatic Cancer After Prior Chemotherapy.
Pancreas
RTOG 0848
A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma..
Prostate
CALGB 90203
A Randomized Phase III Study Of Radical Prostatectomy Alone Versus Estramustine And Docetaxel Before Radical Prostatectomy For Patients With High-Risk Localized Disease.
Prostate
RTOG 0534
A Phase III Trial Of Short Term Androgen Deprivation With Pelvic Lymph Node Or Prostate Bed Only Radiotherapy (Support) In Prostate Cancer Patients With A Rising Psa After Radical Prostatectom
Prostate
SWOG S1216
A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + Tak-700 With Androgen Deprivation Therapy + Bicalutamide In Patients With Newly Diagnosed Metastatic Hormone Sensitive Prostate Cancer
Renal
Alliance A031203
Randomized Phase II Study Comparing Cabozantinib (NSC #761968 and IND #116059) with Commercially Supplied Sunitinib in Patients with Previously Untreated Locally Advanced or Metastatic Renal Cell Carcinoma.
Renal
ECOG E2810
Randomized, Double-Blind Phase III Study of Pazopanib vs. Placebo in Patients with Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease Following Metastatectomy.
Renal
SWOG 0931
EVEREST: EVErolimus for Renal Cancer Ensuing Surgical Therapy, A Phase III Study.
Uterine
GOG 0238
A Randomized Trial Of Pelvic Irradiation With Or Without Concurrent Weekly Cisplatin In Patients With Pelvic-Only Recurrence Of Carcinoma Of The Uterine Corpus